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It is reported that in around 266 elderly participants over six to eight years an approximately 1.6- to 1.8-fold reduction in all-cause mortality was observed, and over a period of 15 years even an approximately 2.5-fold reduction when the pineal peptides were combined with a thymus peptide

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2.2.2 The inflammatory cascade activated by surgical trauma The major surgical trauma of esophagectomy inevitably leads to extensive tissue damage, ischemia-reperfusion injury, and endotoxin translocation, thereby triggering a violent acute inflammatory response (44)