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Novel formulations such as lipid nanoparticles, esterified derivatives, or intranasal carriers should be systematically compared for pharmacokinetics, bloodbrain barrier penetration, and clinical efficacy

For some individuals without insurance coverage, compounded medications may also represent a lower-cost option

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One major problem, however, is that the histopathological diagnosis itself is not based upon the search of a single (or a few), objective, and easily reproducible morphological diagnostic feature(s) but rather, it is born by a constellation of diagnostic criteria whose implementation, meaning, and relative weight considerably vary case by case and is responsible for a worrisome list of diagnostic pitfalls ( Table 1 )