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Also, IGF-1 signaling can affect endothelial function and vascular permeability, possibly adding to fluid buildup in tissues

These include other FDA-approved weight management medications such as phentermine-topiramate (Qsymia), naltrexone-bupropion (Contrave), or orlistat (Xenical, Alli), though these agents generally produce less weight loss than GLP-1 medications

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FOXO4-DRI 10mg (also known as FOXO4-D-Retro-Inverso or Proxofim) is a synthetic, cell-permeable peptide designed as a D-retro-inverso (DRI) analog mimicking a key interaction domain of the Forkhead box protein O4 (FOXO4) transcription factor