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Description

Mechanistically, K145 deacetylation enhances the ubiquitin-binding capacity at lysine 63 (K63), triggering LONP1 degradation

Paramita et al., 2021

10.1111/apa.12735 Acta Paediatr

The presence of an ordered R-domain position poses a surprise, since many alternate models exist for the R-domain mechanism that include a completely disordered R-domain or an R-domain that resides only between NBD1 and NBD2 in a semi-ordered state