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Using a transgenic APP/PS1 mouse model of AD to characterize the effects of long-term GLP-1 receptor agonist administration, Hlscher and colleagues have reported lowered levels of important markers associated with AD neuropathology, including amyloid plaque load, astrogliosis, microglial activation, and central insulin resistance [1517]

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For comparison purpose, the entire stomach (fundus+antrum), ileum, and colon mucosa were scrapped and homogenized as above in the presence of the DPP-4 inhibitor for total and active GLP-1 RIA assay