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its blockade increases serotonin release Promotes neurogenesis : TREK-1 knockout mice show increased hippocampal neurogenesis, and PE-22-28 recapitulates this effect pharmacologically within 4 days of treatment Induces synaptogenesis : TREK-1 blockade promotes dendritic growth and synaptic connection formation PE-22-28 inhibits TREK-1 with an IC50 of 0.12 nM, making it approximately 300-500 times more potent than spadin

Retatrutide storage matrix State Lyophilized (Powder Form), sealed Storage -4F (-20C) or below (freezer) Notes Long-term, up to 12+ months State Lyophilized (Powder Form), sealed Storage 35.6-46.4F (2-8C) (refrigerator) Notes Several months State Lyophilized (Powder Form), shipping Storage Room temperature short-term Notes Stable for several weeks