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These effects were dose-dependent, emerging only at 50 mg/kg/daya level still classified as safe in animals by regulatory standards

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[PMC free article: PMC6632590] [PubMed: 20427668] 208

The anti-apoptotic subgroup encompasses BCL-2, BCL-XL, BCL-W, MCL-1, and A1/BFL-1, with BCL-2, BCL-XL, and BCL-W exhibiting remarkable stability and prolonged half-lives, in contrast to the rapid proteasomal degradation of MCL-1 and A1/BFL-1 through ubiquitination [41, 42]