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2.2.1 TGF- TGF- is the most potent pro-fibrotic mediator, inducing ECM, EMT, and pro-fibrotic mediators production by promoting the binding of Smad2/3 to Smad4, and driving myofibroblast differentiation to promote the PF process (Hu et al., 2018

35 Nausea can be addressed in several of different ways: if receiving a titratable GLP-1RA, return to the previous dose or premeal interval that did not cause symptoms (maximal tolerated dose) give a nontitratable GLP-1RA on a full stomach consider antiemetics for intractable symptoms