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481,482 (4) A fourth targeted drug approach is the activation of PPAR- in mature adipocytes that then induces altered expression of several genes (increased GLUT4 and adiponectin expression, along with decreased TNF-, IL-6 and leptin expression) involved in the insulin signaling cascade, thereby improving insulin sensitivity

Experiencing physical discomfort driving her to binge, and then relief that the medication provided, Megan realized how much of her disorder was a biological condition, and not just a matter of discipline

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