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323,324,325 Specifically, activation of GLP-1R leads to an increase in cAMP levels, which in turn activates PKA, a widely regulating enzyme of cellular functions, capable of phosphorylating a variety of target proteins, thereby initiating the PKA/CREB signaling pathway

Additionally, a dose-dependent increase in the B-cell lymphoma 2 (BCL-2)/Bcl-2associated X protein (BAX) was observed, indicating a shift toward cell survival

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