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On the contrary, it acts as a compulsory exchanger, mediating the influx of leucine into the cell and the efflux of glutamine out of the cell [29, 42]

Efficacy and safety of co-administered once-weekly cagrilintide 24 mg with once-weekly semaglutide 24 mg in type 2 diabetes: A multicentre, randomised, double-blind, active-controlled, phase 2 trial

In the STEP2 focusing on 1,210 patients with obesity or overweight and T2D, average weight loss with semaglutide 2.4 mg therapy was 6.2% compared to the placebo [47]

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