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There are important differences among the opioid overdose reversal agents, such as route of administration, product strength, approved patient age range, and pharmacokinetics

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To obtain plasma, typically whole blood is collected into tubes pre-coated with an anticoagulantheparin and EDTA being the most commonand then transported to the laboratory on wet ice where the whole blood is centrifuged to fraction the sample into its component parts (red blood cells, white blood cells, and plasma)

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