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Side Effect Profiles Whether semaglutide comes in a pill or injection, the most common side effects are the same: Stomach pain Yellow skin or eyes Fever Sweating Dizziness Anxiety Nausea Bloating Vomiting Constipation Diarrhea Faster heartbeat Shakiness or weakness Headaches Blurred vision Fatigue Interestingly, oral and injectable options have about the same risk of adverse side effects

New studies are being designed and conducted to evaluate potential suicidality or depressive symptoms associated with GLP-1 RAs prescriptions

Qualifying Comorbidities FDA labeling and clinical guidelines commonly recognize: Hypertension (blood pressure 130/80 or taking antihypertensive medication) Type 2 diabetes (HbA1c 6.5% or on glucose-lowering medication) Prediabetes (HbA1c 5.7-6.4% or impaired fasting glucose) Dyslipidemia (elevated LDL, low HDL, or elevated triglycerides) Obstructive sleep apnea (diagnosed via sleep study) Cardiovascular disease (prior MI, stroke, coronary artery disease) Non-alcoholic fatty liver disease / MASLD Polycystic ovary syndrome (PCOS) with metabolic features Osteoarthritis weight-bearing joints Insurance formularies may be stricter some require objective documentation (lab values, sleep study reports) rather than self-report

Oral semaglutide vs injectable GLP-1 medications: key differences for weight loss While the chemistry is the same, the lifestyle commitment is different