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If you are really low you may need to do an injection every week for for or five weeks before you notice changes

Russo VA, Van Acker MM, Vander Wal JS, Sinha AA

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showed that supplementation of synbiotics (a combination of probiotics and prebiotics) can relieve constipation in patients with hypothyroidism and is beneficial to thyroid function, but no effect on thyroid peroxidase has been observed [165]