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Wie andere GLP-1-Rezeptoragonisten soll auch Orforglipron potenzielle Vorteile neben Blutzuckerkontrolle und Gewichtsverlust bieten

It acts as a GLP-1 receptor agonist, mimicking the hormone glucagon-like peptide-1 (GLP-1), which regulates appetite and blood sugar levels by affecting insulin and glucagon production

Semin Arthritis Rheum 30:8799 Murphy R, McConell G, Cameron-Smith D et al (2001) Creatine transporter protein content, localization, and gene expression in rat skeletal muscle

While there is currently no conclusive evidence for disease-modifying efficacy on any of the numerous efforts, we summarize recent late-stage clinical trial evidence focusing on glucagon-like peptide 1 (GLP1) agonists, approaches targeting the glucocerebrosidase (GBA) pathway and inhibition of the leucinerich repeat kinase 2 (LRRK2), as well as -synuclein based treatments