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Its expression extends beyond plasma, permeating various tissues, including the kidney, retina, thyroid, lungs, adipose tissue, heart, liver, gastrointestinal tract, brain, mammary gland and appendix [31] (Figure 1b)

The cardiorenal effects of both GLP-1RA and SGLT-2 inhibitors can be summarized as follows: GLP-1RA have moderate benefits on MACE (major cardiovascular events), may reduce all-cause mortality and hospitalization for HF (HHF), and have a robust effect in reducing the incidence of macroalbuminuria [12]

,2010 Jan;7(1 Pt 1):269-76

PMCID: PMC4404515 ) He L, Wang J, Ping F, Yang N, Huang J, Li Y, Xu L, Li W, Zhang H (2022) Association of glucagon-like peptide-1 receptor agonist use with risk of gallbladder and biliary diseases: a systematic review and meta-analysis of randomized clinical trials