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196,197,198 The phosphorylation of Akt is necessary for its full activation, allowing it to regulate a variety of downstream effector proteins involved in cell survival, proliferation, metabolism, and glucose transport

15 Studies have indicated that GLP-1R KO mice exhibit greater numbers of osteoclasts and greater bone resorption than wild-type controls

Around 40-50% of GLP-1 users report nausea or bloating in the early stages of treatment, though symptoms should settle in the first 4-8 weeks as the body adapts (2)

Fatty foods slow gastric emptying further on top of the medication's effect, compounding the problem