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For example, in cultured endothelial cells, lipoic acid was found to inhibit IKK-, an enzyme that promotes the translocation of redox-sensitive and pro-inflammatory transcription factor, nuclear factor-kappa B (NFB) from the cytosol to the nucleus (46)

Pregnant or lactating women and individuals with medical conditions should consult a healthcare professional before use

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The other drawback is that some people who are sensitive to higher histamine levels or who have mast cell activation syndrome report that NAC gives them a histamine reaction