Materials and methods Search strategy A comprehensive literature search was performed in the database PubMed
When activated, these receptors trigger several beneficial effects: Enhanced insulin secretion in response to elevated blood glucose levels Suppression of glucagon release , reducing hepatic glucose production Delayed gastric emptying , which promotes satiety and reduces appetite Direct effects on appetite centres in the hypothalamus, leading to reduced food intake Commonly prescribed GLP-1 receptor agonists available in the UK include semaglutide (Ozempic, Wegovy, Rybelsus), dulaglutide (Trulicity), liraglutide (Victoza, Saxenda), and exenatide (Byetta, Bydureon)
Previous GLP-1 agonist cardiovascular trials were conducted primarily in diabetic populations, leaving open the question of whether the heart benefits were mediated through glucose management or through direct cardiovascular effects of GLP-1 receptor activation
One simple tip is to set reminders on your phone to check the storage conditions of your medication regularly
